Mohammad Jalali
Shiraz University of Medical Sciences, Iran
Title: Effect of cinnamon supplementation on glycemic indices and lipid profiles in type 2 diabetic patients: a systematic review and meta-Analysis of clinical trials
Biography
Biography: Mohammad Jalali
Abstract
Statement of the Problem: Diabetes mellitus is a complicated and metabolic disorder characterized by an increase in blood glucose level as a result of insulin resistance, impairment in insulin release, or both. In 2013, it had reported that 382 million people had type 2 diabetes mellitus (T2DM) worldwide and this number is expected to reach 592 million in 2035. However, in some studies cinnamon proved useful to treat T2DM, some others did not find a favorable effect. A present systematic review and meta-analysis aimed to provide more robust evidence on the use of cinnamon for treating T2DM.
Methodology & Theoretical Orientation: A systematic search was undertaken in PubMed, Embase, Scopus, Web of Sciences and Cochrane Library to identify clinical trials examining the effect of cinnamon supplementation on type 2 diabetic patients up to 9 August 2019. In the case of heterogeneity among studies, fixed or random effects models were done to calculate standardized mean difference (SMD) and its 95% confidence interval (CI).
Findings: After excluding nonrelated records, 14 full-text articles included to this meta-analysis. This study found a significant reduction in Fasting blood sugar (FBS) (SMD: -0.472 mg/dl, 95% CI: [-0.791, -0.153], P = 0.004), serum triglyceride (TG) (SMD: -0.538 mg/dl, 95% CI: [-0.933, -0.143], P = 0.008), total serum cholesterol (SMD: -0.580 mg/dl, 95% CI: [-1.080, -0.080], P = 0.023) and increase in high-density lipoprotein (HDL) (SMD: 0.167 mg/dl, 95% CI: [0.014, 0.320], P = 0.032). In addition, dose-based subgroup analysis indicated significant reduction in HbA1c, serum insulin and low-density lipoprotein (LDL). Also, no publication bias was found.
Conclusion & Significance: Cinnamon supplementation significantly improved FBS, TG, total serum cholesterol and HDL, with subgroup analysis highlighting improvements in HbA1c, serum insulin and LDL.