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Pedro A. Jose

Pedro A. Jose

The George Washington University


Dr. Pedro A. Jose is Professor of Medicine and Pharmacology/Physiology, The George Washington University School of Medicine & Health Sciences, Visiting Professor, Third Military Medical University, Chongqing, China, Visiting Professor, Anhui Institute of Cardiovascular Disease, Anhui, China, and Concurrent Professor, Nanjing University School of Medicine, Nanjing, China. The primary goal of Dr. Jose’s research is to determine the genetic and pharmacogenetic bases of human essential hypertension and the metabolic syndrome. Specifically, the mission of his laboratory is to study the role of dopamine, adrenergic, and angiotensin receptor subtypes and dopamine regulatory genes (e.g., G protein-coupled receptor kinase 4 [GRK4], sorting nexins, gastrin) on sodium transport in specific nephron segments and their roles in the pathogenesis and treatment of genetic hypertension and metabolic syndrome. Dr. Jose’s studies are performed in vitro and in vivo, using molecular and cell biological methods, including gene silencing, gene rescue (e.g., AAV vectors), confocal microscopy and biophysical imaging, and integrated physiology in rats, mice, and humans. A key finding of Dr. Jose’s research is the demonstration of the crucial role of gene variants of GRK4 in the pathogenesis and personalized treatment of hypertension. Dr. Jose and his associates have discovered genes that cause high blood pressure when sodium intake is excessive and more importantly, genes that cause high blood pressure when sodium intake is too low. He has published more than 380 scientific articles in book chapters and journals. His articles are currently cited more than 10,000 times, with 57 cited 50 or more times, 19 of which are cited more than 100 times. Four of his articles are covers of scientific journals, six are the subject of editorial commentaries, and two are featured articles. His Hirsch-index is 52. Dr. Jose has received several academic and research awards, including the 2003 Lewis K. Dahl Memorial Lecture (American Heart Association), 2007 Ernest H. Starling Distinguished Lecture (American Physiological Society), 2007 MERIT award (National Institutes of Health), and 2015 Excellence Award for Hypertension Research (American Heart Association).

Research Interest

Metabolic syndrome, Pharmacology, Health Sciences.